Magus Tech Chapter 355: Sulfa and zero waves and stones
"In the current wizarding world similar to the Middle Ages, it is very difficult to use penicillin to treat infected pneumonia." Li Cha had this idea in his mind, "And penicillin can only kill some bacteria, and has almost no effect on fungi. , it is best to dispel this idea.”
So, if you don't use penicillin, what do you use?
The answer to this question is - sulfa.
Penicillin is the first antibacterial drug discovered in the world, and it is also the most widely used antibacterial drug on the modern earth, but it is not the first antibacterial drug to be widely used.
1930s——Penicillin was discovered, but in the process of trying to increase production, sulfa drugs have been used as effective drugs for the treatment of hemolytic streptococcal infections and used in clinical treatment.
In the next ten years, sulfa drugs developed rapidly. By the 1940s, hundreds of different sulfa drugs had been produced.
During the early part of World War II (1939-1945), sulfonamides were a common drug used by the military to treat infections. There are sulfa powder and sulfa pills in the first aid kit of the US military. The sulfa powder can be sprinkled on the wound to inhibit infection, and the sulfa pill can be taken orally to deal with gangrene and pneumonia.
Well, pneumonia.
Sulfa drugs saved many lives during the war, including big names such as Franklin Delano Roosevelt Jr. - son of US President Roosevelt, and Winston Churchill with pneumonia - UK prime minister.
Therefore, no matter how you look at it, under the premise that penicillin is unreliable, sulfonamide is the real life-saving straw.
But it is too early to say that all problems have been solved.
If you think about it carefully, sulfonamide cannot be produced casually, otherwise such an important thing would not be used as a clinical treatment until before World War II.
The reason for this is that sulfanilamide is a chemically synthesized drug, a derivative of p-aminobenzenesulfonamide. In other words, in order to manufacture it, a certain level of chemical industry is required.
This level is to reach the level of the earth in the 1900s, because this is the time when the first sulfanilamide derivatives were chemically synthesized.
The original synthesis was not used as a therapeutic drug. At the beginning, people did not realize the magical effect of this kind of thing, but simply regarded it as... a dye.
Yes, dye.
Synthetic products, with bright colors and almost no fading, are superior to all previous dyes and are widely used in the dyeing industry.
It is worth mentioning that the color of this dye is red.
Well, red.
So how did this red dye finally become a medicine after decades?
This mainly relies on the very brainy German scientist-Hard Dormark.
In the autumn of 1932, Dormark worked for Farben, hoping to find a drug that could specifically kill pathogenic bacteria. After some consideration, he decided to start with a bacterial stain.
Domark's logic is this: the dye can change the color of the bacteria, which means that some special changes have taken place in the internal structure of the bacteria. As long as a dye is found that can only change the color of specific bacteria and destroy the internal structure of the bacteria without affecting the rest of the cells, isn't it an excellent specific antibacterial drug?
Through continuous efforts, Domac discovered the red azo dye—Burnadox from thousands of candidate azo dyes.
After research, Pronoccus has a strong effect on the treatment of hemolytic streptococcal infection.
Relying on the many breaths of waves, Domark rescued his daughter who was suffering from streptococcal septicemia due to infection at one stroke, and won the Nobel Prize in Medicine in 1939.
The mechanism of Prontosil is a prodrug, that is, it has no activity in vitro, but after entering the organism, it can decompose the derivative of p-aminobenzenesulfonamide—sulfonamide. Sulfa and the p-aminobenzoic acid needed for the growth of bacteria are very similar in chemical structure, which will allow the bacteria to absorb it misleadingly but have no effect, and eventually die.
Truthfully speaking, the biggest effect of Prontosil is actually to inhibit germs, not to kill them, which is different from penicillin.
In addition, Bailang Duoxi has a disadvantage that cannot be ignored, that is, after use, it will make people's body change color, because it is a dye after all.
But anyway, he is indeed a life-saving drug.
So how do you get it?
The way to obtain it is generally to put p-aminobenzenesulfonamide in an alkaline solution and use potassium ferricyanide or potassium permanganate to oxidatively couple amino groups to synthesize it. It can also be synthesized by reductive coupling of p-nitrobenzenesulfonamide with zinc powder.
All in all, all in all, it's troublesome.
It's not impossible, but because there is no chemical industry level corresponding to the modern earth at the beginning of the 20th century, many raw materials need extra preparation. And the raw material of making raw material needs the raw material preparation that does not exist in addition.
So there is a need for raw materials for raw materials.
What makes people collapse is that the raw materials of raw materials often do not exist in nature, and they still need to be produced-under the premise of lacking a complete industrial system, they often have to face and want to synthesize something across the ages Therefore, in addition to opportunism and finding another way, it is necessary to establish a small half of the industrial system that is lacking.
However, Li Cha doesn't have to experience this kind of inner breakdown.
Because a hundred waves rest forever, he owns it.
Yes, he has a hundred waves and more breaths!
Red dye, with high medicinal value, isn't it what Alex sent in the box before!
At the beginning, he realized the value of the dye and accepted it, but now it's time to use it.
Thinking like this, Li Cha supported his tired and weak body, and walked towards the wooden frame next to him.
…
Outside the laboratory, in the yard.
Pandora stood, frowning, not understanding why Richard drove her out, did she do something wrong?
No, she was very obedient during this period of time, and even offered to help clean the test tube. Maybe in the process of washing the test tubes, I broke a few...dozens...well, I broke a few hundred, but she couldn't blame it all.
Who made the test tube slippery, it is very difficult to grasp, especially if it is contaminated with water, it will fall to the ground if you are not careful. She grabbed it with such great strength in order not to break it, and it was completely understandable that she accidentally crushed it.
Or...
Pandora remembered the pale face of Li Cha she saw before.
"Da da da..."
Pandora quickly ran to the window, grabbed the window sill, stood on tiptoe vigorously, and looked into the laboratory.
Through the cloudy glass, Pandora saw that Li Cha was frowning tightly, drinking the strange liquid, and then forced himself to do some things, looking very strenuous.
She should help.
Pandora thought so, and suddenly saw Li Cha in the laboratory approaching the window sill, covering his mouth and nose, knocking on the irregular glass on the window, and said to her: "Be good, be careful Stay in the yard, don't think about coming in. Don't worry about me, I'm fine."
"Ah——" Pandora said, let go of the window sill ~IndoMTL.com~ and walked back to the middle of the yard, pursing her lips and walking sullenly. A long stone of more than 20 centimeters stood in front of it without eyes. Pandora kicked it away, and the stone rolled out.
Suddenly, Pandora turned her head and looked at the kicked stone. Her eyes flickered, and she turned her head to look at the laboratory again, as if thinking of something.
Running quickly to the side of the kicked stone, Pandora picked it up, then found another stone and held it in her hand, trying to start beating.
"Bang bang bang..."
Pandora beat it very carefully, much more carefully than when washing the test tubes, and the 20 cm long stones dropped debris little by little.
Pandora stopped beating for a while, tilted her head and thought for a long time, and then continued beating.
In the intermittent voice, the long stone in Pandora's hand slowly took shape - a human shape.
In the laboratory, after Li Cha took Bailang Duoxi, he was carrying out the rest of the auxiliary treatment.
The sky is dark, and the night continues...